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Is Testosterone Therapy Safe for Women? Large Study Finds No Increased Heart or Breast Cancer Risk

Article: "Testosterone Therapy in Females Is Not Associated with Increased Cardiovascular or Breast Cancer Risk: A Claims Database Analysis" (Agrawal, Singh, Hsueh et al. — The Journal of Sexual Medicine, 2024) 

 

A large study published in The Journal of Sexual Medicine analyzed over 10,000 women using the TriNetX Diamond Network, a real-world database of approximately 200 million patients. Researchers found that women receiving testosterone therapy had significantly lower rates of major adverse cardiovascular events (MACE), including a 36% reduction in risk, as well as lower rates of deep vein thrombosis (39%), pulmonary embolism (52%), and malignant breast cancer (52%) compared to matched controls. Notably, these findings remained consistent in postmenopausal women, a population traditionally considered at higher cardiovascular risk. 

These results contribute to a growing body of evidence suggesting that testosterone may play a role in cardiovascular health through effects on vascular function, inflammation, and metabolic regulation. While hormone therapy itself is outside the scope of cardiovascular imaging, understanding an individual’s underlying heart disease risk remains critical. 

Advanced imaging techniques such as coronary CT angiography (CCTA) and calcium scoring can provide valuable insight into early cardiovascular disease and help guide prevention strategies. Speak with our team to learn more about whether advanced cardiac imaging is right for you. 

 

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